One North Carolina Small Business Program

The One North Carolina Small Business Program is comprised of two programs:

  • The SBIR/STTR Phase I Incentive Funds Program.
  • The SBIR/STTR Phase I Matching Funds Program.

As authorized by North Carolina General Statute § 143B‑437.80 the SBIR/STTR Phase I Incentive Funds Program provides reimbursement to qualified North Carolina businesses for a portion of the costs incurred in preparing and submitting Phase I SBIR or STTR proposals to federal agencies. 

As authorized by North Carolina General Statute § 143B‑437.81 the SBIR/STTR Phase I Matching Funds Program awards matching funds to North Carolina businesses who have received a federal Phase I Small Business Innovation Research (SBIR) Program or Small Business Technology Transfer (STTR) award.

There are currently no active solicitations for either of these programs. For additional information regarding solicitations, see Current Solicitation & Guidelines or Previous Solicitations & Awardees below.

To learn about the impacts of this program, see Grant Program Impacts and the latest press release on awarded grants: 29 Small Technology Companies Win Innovation Grants (February 2, 2021).

To learn about how six Program grantees are combating COVID-19, see the One NC Small Business Programs COVID-19 Fact Sheet.

The One North Carolina Small Business Program is administered by the Office of Science, Technology & Innovation on behalf of the Board of Science, Technology & Innovation.

Amended Guidelines

Amended Guidelines

The Fiscal Year 2021-2022 North Carolina state budget (SL 2021-180, pages 283-284), enacted on November 18, 2021, includes changes to the statutory provisions authorizing the One North Carolina Small Business Incentive Program and Matching Program. Those changes necessitate amendments to the respective Guidelines for the Programs. Program Guidelines are more general and overarching than specific Program Solicitations and govern the administration of the Programs on an ongoing basis.

As required by North Carolina General Statute 143B-437.82, the North Carolina Department of Commerce is publishing for public comment the attached proposed amendments to the Guidelines for the Programs. Comments will be accepted for 15 business days beginning Tuesday, November 23, 2021. The amended, finalized Guidelines will take effect on December 16, 2021, and Program Solicitations will be available soon thereafter.

For an overview of the Guidelines amendment process, see the following files:

Current Solicitation & Guidelines

Current Solicitation & Guidelines

On November 18, 2021, the North Carolina General Assembly and Governor enacted a Fiscal Year 2022 (July 1, 2021-June 30, 2022) budget. The budget includes $5 million for the One NC Small Business Program. The budget has to be certified before a One North Carolina Small Business Program can be issued. This process may not be complete until mid-late December. As soon as it is complete, a solicitation will be available here and notifications will be distributed to the media, previous grantees, and other organizations that work with SBIR/STTR applicants and grantees. 

For previous solicitations, see Previous Solicitations & Awardees.

For general eligibility requirements, please see the Program Guidelines.

If you have questions, please contact the OSTI staff.

Program Impacts & Success Stories

Program Impacts & Success Stories

Program Impacts

In 2017, a detailed analysis of the One NC Small Business Matching Funds Program impacts was conducted. The evaluation found that, since its inception in 2006, the program has helped enable:

  • the creation and retention of nearly 900 private sector jobs statewide – more to come as more companies benefit and grow.
  • more than 250 small businesses bring to market biotechnology, nanotechnology, medical technologies, computer software, military/defense technologies, pharmaceuticals, textiles, and other high-tech applications.
  • more than 77 percent of the small businesses to remain in operation.
  • the small businesses to attract more than $515 million in external investment, including more than $122 million in follow-on federal funds.
  • 60 percent of NC matching grant winners to win Phase II federal grant awards, each with a considerably larger average value of $1 million (nationally, 54 percent of Phase I award winners graduate to Phase II awards).
  • the small businesses to produce more than $125 million in total first-year sales resulting directly from the technology developed with Program funding.
  • significant technology/business-development partnerships among NC universities & businesses.

For a printable two-page summary of the strong impacts of the One NC Small Business Program since its inception in 2006, see:

For an economic impact analysis of the overall impacts on North Carolina’s economy resulting from the increased number of employees that North Carolina small businesses created with the One NC Small Business Program grants between 2006 and 2018, see:

Success Stories

  • Applied LifeSciences & Systems (Raleigh) - Biosystems Company Builds Technology That Reduces Business Costs & Improves Animal Welfare
  • Baebies (Durham) - Innovating a Healthy Start for Babies and a Diagnostic Company
  • Bennett Aerospace (Cary) - Smart Engineering Creates New Products & A Successful Company
  • Corvid Technologies (Mooresville) - One North Carolina Small Business Program Supports Engineering Firm's Overwhelming Growth
  • Precision BioSciences (Durham) - Cutting-Edge Leadership in a New Technology Can Cut Both Ways
  • Prevention Strategies (Greensboro) - Preventing Bad Behavior Alone Doesn't Lead to Business Success
  • Ribometrix (Durham) - Innovative Treatment Strategy for Human Disease Shapes a Successful Biotech Company
  • United Protective Technologies (Locust) - Thin Coatings Protect Military Investments and Facilitate Small Business Growth
  • Vigilant CyberSystems (Mt. Airy) - Surviving Threats in Cyberspace and The Tough World of Business
Awardee Small Businesses

Awardee Small Businesses

Since its inception in 2006, the program has awarded grants to 290 small businesses throughout the state. Those businesses are listed below; links to their websites are provided when available. Additional detail regarding awardee small businesses is available at Previous Solicitations & Awardees.

0 Base Design, LLC
3-C Institute for Social Development, Inc.
3TEX, Inc.
4pi Analysis, Inc.
A-B-Sea Research, Inc.
Adamas Nanotechnologies, Inc.
Adroit Materials, Inc.
Advanced Digital Systems, Inc.
Advanced Hydrogen Technologies Corporation
Advanced Liquid Logic, Inc.
Advanced TeleCare, LLC
Affinergy, LLC
Agile Sciences, Inc.
AI Tracking Solutions, LLC
Air Control Techniques, P.C.
Akoustis, Inc.
Alderon Biosciences, Inc. 
Alditri Technologies, Inc.
Algaen Corporation 
Allotropica Technologies, Inc.
Altis Biosystems, Inc.
Altometrics, Inc.
Ambient Logic, LLC
AP Solutions, Inc.
Appealing Products, Inc.
Applied LifeSciences & Systems, LLC
Applied Quantum Technologies, Inc.
Applied Science International, LLC
Arcato Laboratories, Inc.
Arctic, Inc.
ArrayXpress, Inc.
Arrevus, Inc.
Asklepios BioPharmaceutical, Inc.
Assist Equipment Development, Inc.
Atom Bioworks, Inc.
Auger Communications, Inc.
AURA Technologies, LLC
AxNano, LLC
b3 bio, Inc.
Baebies, Inc.
Bear Fiber, Inc.
Bedrock Therapeutics, Inc.
Bennett Aerospace, Inc.
Biofluidica, Inc.
Biographics, Inc.
BioKier, Inc.
BioLink Life Sciences, Inc. 
BioMarck Pharmaceutical, Ltd.
BioMedomics, Inc.
BioMojo, LLC
Bioptigen, Inc.
Black Velvet Solar, Inc.
Blue Ridge Research and Consulting, LLC
BotaniPharm, LLC
Brighton Development, LLC
Broad Digital, LLC
Camras Vision, Inc.
Capture Pharmaceutical, Inc.
Carolina Unmanned Vehicles, Inc.
CD Neural Technologies, Inc.
Cell Microsystems, Inc.
Celldom, Inc.
Cellf BIO, LLC
Chaperone Therapeutics, Inc.
Cirque Productions, LLC
CivaTech Oncology, Inc.
Clairvoyant Technology, LLC
Clinical Sensors, Inc.
Clinical Tools, Inc.
Cloud Solutions, LLC
Cognosci, Inc.
Collaborations Pharmaceuticals, Inc.
Corvid Technologies, LLC
CP Diagnositics, Inc.
Creative Bioreactor Designs, Inc.
Creative Scientist, Inc.
CryoFacets, Inc. 
CTW Development Company, LLC
Cytex Therapeutics, Inc.
Dignify Therapeutics, LLC
Dot Metrics Technologies, Inc.
Edison Agrosciences, Inc.
Element Genomics, Inc.
EncepHeal Therapeutics, Inc.
Endacea, Inc.
EnergyXchain, LLC
Enformia, Inc.
Eno River Labs, LLC
Eno River Technologies Co., LLC
Entertainment Science & Virtual Heroes Joint Venture, Inc.
Enzerna Biosciences, LLC
EpiCypher, Inc. 
Eppin Pharma, Inc.
Ercole Biotech, Inc.
Eyedesis Biosciences, LLC
Falcon Therapeutics, Inc.
Firebird Advanced Materials, Inc.
Foard Systems Design, Inc. 
Fokuslabs Behavioral Solutions, Inc.
Forthright Engineering, PLLC
Galaxy Diagnostics, Inc.
GEM Tox Consultants and Labs, Inc.
Geometric Data Analytics, Inc.
Gigabeam Acquisition Corporation
Goldfinch Sensor Technologies and Analytics, LLC
GrassRoots Biotechnology, Inc.
GreatWall Systems, Inc.
GridBridge, Inc.
GTCAllison, LLC
G-Zero Therapeutics, Inc.
Haw River Mushrooms, LLC
Health Outcomes, Inc. 
HealthSpan Diagnostics, LLC
HepatoSys, Inc.
Horizon Performance, LLC
Humacyte, Inc.
Identizyme Defense Technologies, Inc.
Impulsonic, Inc.
Inanovate, Inc.
Independent Living Resources, Inc.
Indexus Biomedical, LLC
IngateyGen, LLC
Initos Pharmaceuticals, LLC
Innatrix, Inc.
InnAVasc Medical, Inc.
InnerOptic Technology, Inc.
InnovaTech, Inc.
Innovation Research and Training, Inc.
Insect Diet and Rearing Research, LLC
InsituTec, Inc.
Integrated Laboratory Systems, Inc.
Integrated Oncology Solutions, Inc.
Intelli-Products, Inc.
International Association of Virtual Organizations, Inc.
Interventional Analgesix, Inc.
Isolere Bio, Inc.
Keona Health, Inc.
Kepley Biosystems, Inc.
KeraNetics, LLC
Kyma Technologies, Inc.
LaamScience, Inc.
Laser Biopsy, Inc.
LifeSciTech, LLC
Liquidia Technologies, Inc.
Lumedica, Inc.
Lupine Materials and Technology, Inc.
MAA Laboratories, Inc.
ManningRF, LLC
Materials Innovation Technologies, LLC
Maverick BioFuels, Inc.
Mercury Science, Inc.
Metalytics, LLC
Microgrid Labs, Inc.
Microphase Coatings, Inc.
Morphormics, Inc.
MoveableCode, Inc.
MRI Cardiac Services, Inc.
MRPath, Inc.
Mucommune, LLC
Murano Corporation
Multi3D, LLC
MuukLabs, Inc.
Mycosynthetix, Inc.
Nanodiagnostic Technology, LLC
Nanolytics, Inc.
NanoTechLabs, Inc.
NanoVector, Inc.
NCO Technologies, LLC
Nekton Research, LLC
Neuro10-9 Pharma, Inc.
New Jersey Microsystems, Inc.
NIRvana Pharmaceuticals, Inc.
NIRvana Sciences, Inc.
Nitronex Corporation
Nocturnal Product Development, LLC
Novan, Inc.
NovaTarg, Inc.
Nuvotronics, Inc.
Oncoscope, Inc.
OncoTAb, Inc.
Onda Vision Technologies, Inc.
OpSource, Inc.
Optopo, Inc.
Optosonics, Inc.
Orbit Energy, Inc.
Parion Sciences, Inc.
Path BioAnalytics, Inc.
Perotech, Inc.
Phase Bioscience, Inc.
PhotoCide Protection, Inc.
PhotonTech, LLC
Physcient, Inc.
Piedmont Biofuels Industrial, Inc.
Plakous Therapeutics, Inc.
Plasma Games, Inc. (formerly Athena's Compass)
Plureon Corporation
Polarean, Inc.
Polyglot Systems, Inc.
Praetego, Inc.
Precision BioSciences, Inc.
Precision Human Biolaboratory Inc./Ridge Diagnostics
Predictive, LLC
Premitec, Inc.
Prevention Strategies, LLC
PrimeNeuro, Inc.
Protochips, Inc.
Proventys, Inc.
Pulvinar Neuro, LLC
Puratec, LLC
Qatch Technologies, LLC
Qualiber, Inc.
QuarTek Corporation
Ramona Optics, Inc.
Redbud Labs, Inc.
Religent, Inc.
Rescindo Therapeutics, Inc.
Reveris Therapeutics, LLC
Ribometrix, Inc.
Rivis, Inc.
Roundtable Analytics, Inc.
rPath, Inc.
Science Learning Resources, Inc.
SciKon Innovation, Inc.
ScitoVation, LLC
Scribner Associates, Inc.
SeaTox Research, Inc.
Secmation, LLC
Semprius, Inc.
Signal Innovations Group, Inc.
Sindre Metals, Inc.
SinnovaTek, Inc.
Sirga Advanced Biopharma, Inc.
Solitronics, LLC
SonoVol, Inc.
Southeast TechInventures, Inc.
SoyMeds, Inc.
Stovall Life Science, Inc.
STRAD Corporation
Studio Hagler, LLC
Sun Dance Genetics, LLC
SureMilk, LLC
Susteon, Inc.
Symberix, Inc.
Technical Designs, Inc.
TeleSage Research, Inc.
TeleSwivel, LLC
Tensive Controls, Inc.
The Sandbox Learning Company, Inc.
TheraLogics, Inc.
ThinkZone, LLC
Third Floor Materials, Inc.
Treadwell Corporation
Triad Interactive Media, Inc.
Triad Semiconductor, Inc.
Triangle BioSystems, Inc.
Triangle Biotechnology, Inc.
Triangle Polymer Technologies, Inc.
TriboFilm Research, Inc.
United Protective Technologies, LLC
Upstream Biotechnology, LLC
Vadum, Inc.
Valencell, Inc.
Vascular Biosciences, Inc.
Vascular Pharmaceuticals, Inc.
VeritasCNC, Inc.
Vesta Therapeutics, Inc.
Video Collaboratory, LLC
Vigilant Cyber Systems, Inc.
Virtual Reality Aids, Inc.
Vortant Technologies, LLC
Voxel Innovations, Inc.
Wasatch Photonics, Inc.
Wave Computation Technologies, Inc.
WISER Systems, Inc.
Windlift, LLC
X-In8 Biologicals Corporation
Xintek, Inc.
ZellComp, Inc.
Zenalux Biomedical, Inc.
Zen-Bio, Inc.
Zumatek, Inc.
Zymeron Corporation


Apply to Program

Apply to Program

The program is not currently accepting applications.

If you have any questions, please email the Office of Science, Technology & Innovation.


Submit a Report / Edit an Application

Submit a Report / Edit an Application

Reports and Applications for the One North Carolina Small Business Program are managed through the sciGrants Management System.

To submit reports or a survey, or to edit an already active application for the Program, access the sciGrants Management System using the links below:

If you are ready to request a Stage 2 payment disbursement, contact the staff of the Board of Science, Technology & Innovation.

Previous Solicitations & Awardees

Previous Solicitations & Awardees

The One North Carolina Small Business Program helps small businesses develop and commercialize innovative technologies to benefit the general population. In the process, it helps high-tech businesses attract more funding to the state―keeping home-grown technologies in North Carolina and creating more well-paying jobs.

Previous solicitations and listings of awardees under the Matching Funds program are available for download in the table below.

Fiscal Year Solicitation Award # Award $ Awardees
FY 2021 Solicitation 29 $1,500,000 Awardees
FY 2020
Not Funded
 N/A N/A N/A N/A
FY 2019 Solicitation 25 $1,201,990 Awardees
FY 2018
Not Funded
 N/A N/A N/A N/A
FY 2017 Solicitation 62 $3,686,680 Awardees
FY 2016 Solicitation 40 $1,954,004 Awardees
FY 2015 Solicitation 51 $2,500,000 Awardees
FY 12-14
Not Funded
 N/A  N/A N/A N/A
FY 2011 Solicitation 44 $1,311,513 Awardees
FY 2010 Solicitation 22 $1,018,940 Awardees
FY 2009 Solicitation 54 $3,968,589 Awardees
FY 2008 Solicitation 49 $4,675,952 Awardees
FY 2007 Solicitation 51 $4,553,918 Awardees
FY 2006 Solicitation 25 $1,111,817 Awardees
Total 452 $27,483,401 Awardees

Previous solicitations for the One NC Small Business Incentive Funds Program can be found below:

Legislative Reports

Legislative Reports

The Board of Science, Technology & Innovation provides annual reports on the One North Carolina Small Business Program to the North Carolina General Assembly, as required by North Carolina General Statute § 143B‑437.83.

Copies of these reports are publicly available through the links below: